anafranil
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Question:
Yup…you’ve said a mouthful, or should we say a "mouth-dry" Seriously now, it seems that there is always a down-side to so many of these meds that the doctors feel will help… The best advice is drink lots of water and milk )if you can tollerate it). Tootles Goodie * Sent from RemarQ http://www.remarq.com The Internet’s Discussion Network * The fastest and easiest way to search and participate in Usenet – Free!
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is a good med for me but i really hate the dry mouth! that’s all "Remember, when someone annoys you that it takes 42 muscles to frown, but it only takes 4 muscles to extend your arm and whack them in the head." http://members.aol.com/unfun26/enter.htm
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By all the Gods and Goddesses, we are a highly educated group of people. Kiesha – Hide quoted text — Show quoted text – | ANafranil is an old tricyclic. I _think_ it works on serotonin, | epinephrine, and dopamine. | | Actually, it’s a relatively _new_ tricyclic, and it is fairly selective for | serotonin. (Most tricyclics have no significant effect on dopamine reuptake, | BTW.) | | It was the first drug to be approved in the US for OCD. | | -elizabeth I found articles indicating it was around in 1974 – is that relatively new for tricyclics? Also, while it’s "principal pharmacologic effect in vitro is the selective inhibition of serotonin reuptake, in vivo the drug’s pharmacologic activity is not so selective because of the action of its demethylated metabolite, desmethyclomipramine, as an inhibitor of norepinephrine reuptake." (1997 American Hospital Formulary Service 28:16.04). It goes on to say that "Preliminary evidence suggests that clomipramine may inhibit dopaminergic activity…extensive binding to postsynaptic receptors of dopamine antagonists (3h-spiroperidol) in vitro….also increases the CSF concentration of the dopamine metabolite homovanillic acid secondary to increased dopamine turnover…Because obsessive-compulsive disorder is common in patients with certain disorders of dopamine regulation…additional studies are needed to determine whether these initial findings are clinically important." So while you are correct in saying clomipramine itself selects for serotonin, I believe that the effects of taking it (i.e., including metabolites) include blockade of norepinephrine and dopamine reuptake. -Mike
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| ANafranil is an old tricyclic. I _think_ it works on serotonin, | epinephrine, and dopamine. | | Actually, it’s a relatively _new_ tricyclic, and it is fairly selective for | serotonin. (Most tricyclics have no significant effect on dopamine reuptake, | BTW.) | | It was the first drug to be approved in the US for OCD. | | -elizabeth I found articles indicating it was around in 1974 – is that relatively new for tricyclics? Also, while it’s "principal pharmacologic effect in vitro is the selective inhibition of serotonin reuptake, in vivo the drug’s pharmacologic activity is not so selective because of the action of its demethylated metabolite, desmethyclomipramine, as an inhibitor of norepinephrine reuptake." (1997 American Hospital Formulary Service 28:16.04). It goes on to say that "Preliminary evidence suggests that clomipramine may inhibit dopaminergic activity…extensive binding to postsynaptic receptors of dopamine antagonists (3h-spiroperidol) in vitro….also increases the CSF concentration of the dopamine metabolite homovanillic acid secondary to increased dopamine turnover…Because obsessive-compulsive disorder is common in patients with certain disorders of dopamine regulation…additional studies are needed to determine whether these initial findings are clinically important." So while you are correct in saying clomipramine itself selects for serotonin, I believe that the effects of taking it (i.e., including metabolites) include blockade of norepinephrine and dopamine reuptake. -Mike
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I think Anafranil has been around in Europe longer than it has here in the States. I’m pretty sure it’s one of the newer tricyclics, though – the first one (imipramine) was approved in the US in 1959. The reason why these drugs are called "tricyclics" is because of their three-ringed chemical structure. You can take a look at the molecular structures of various drugs at http://cponline.gsm.com. Hope that clarifies things! -elizabeth
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H. E. Shapere schreef: I think Anafranil has been around in Europe longer than it has here in the States. I’m pretty sure it’s one of the newer tricyclics, though – the first one (imipramine) was approved in the US in 1959. The reason why these drugs are called "tricyclics" is because of their three-ringed chemical structure. You can take a look at the molecular structures of various drugs at http://cponline.gsm.com. Hope that clarifies things! -elizabeth
Thanks, Elizabeth. Will have a look-see at the site you mention. Philip
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| ANafranil is an old tricyclic. I _think_ it works on serotonin, | epinephrine, and dopamine. | | Actually, it’s a relatively _new_ tricyclic, and it is fairly selective for | serotonin. (Most tricyclics have no significant effect on dopamine reuptake, | BTW.) | | It was the first drug to be approved in the US for OCD. | | -elizabeth I found articles indicating it was around in 1974 – is that relatively new for tricyclics? Also, while it’s "principal pharmacologic effect in vitro is the selective inhibition of serotonin reuptake, in vivo the drug’s pharmacologic activity is not so selective because of the action of its demethylated metabolite, desmethyclomipramine, as an inhibitor of norepinephrine reuptake." (1997 American Hospital Formulary Service 28:16.04). It goes on to say that "Preliminary evidence suggests that clomipramine may inhibit dopaminergic activity…extensive binding to postsynaptic receptors of dopamine antagonists (3h-spiroperidol) in vitro….also increases the CSF concentration of the dopamine metabolite homovanillic acid secondary to increased dopamine turnover…Because obsessive-compulsive disorder is common in patients with certain disorders of dopamine regulation…additional studies are needed to determine whether these initial findings are clinically important." So while you are correct in saying clomipramine itself selects for serotonin, I believe that the effects of taking it (i.e., including metabolites) include blockade of norepinephrine and dopamine. -Mike
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H. E. Shapere schreef: ANafranil is an old tricyclic. I _think_ it works on serotonin, epinephrine, and dopamine. Actually, it’s a relatively _new_ tricyclic, and it is fairly selective for serotonin. (Most tricyclics have no significant effect on dopamine reuptake, BTW.) It was the first drug to be approved in the US for OCD. -elizabeth
Relatively new, Elizabeth? I was on Anafranil for eight years starting in…er…(count)..er…(some math)…er…(benzo memory?)….1985 or some years earlier. And then it had been in existence for some time.I always thought they were called *tricyclics* because they do affect dopamine and norepinephrine levels as well as serotonin levels. I have never seen Anafranil listed as an SSRI. Still, you always sound well-informed. Can you clarify this for me? Philip
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ANafranil is an old tricyclic. I _think_ it works on serotonin, epinephrine, and dopamine.
Actually, it’s a relatively _new_ tricyclic, and it is fairly selective for serotonin. (Most tricyclics have no significant effect on dopamine reuptake, BTW.) It was the first drug to be approved in the US for OCD. -elizabeth
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Mike Dedek schreef: ANafranil is an old tricyclic. I _think_ it works on serotonin, epinephrine, and dopamine. It didn’t do me any good except on the higher dose (150mg/day) it caused me to do thinks like fall asleep and off the toilet, wake up on the bedroom floor, etc. At 50mg/day I got more and more depressed (dont’ blame the Anafranil, but it didn’t help). It is primarily indicated for OCD but is also used for panic and depression.
It’s primarily designed for depression really and works for anxiety disorders like PD and OCD as well. In the Netherlands it is *the* most prescribed and very succesful TCA. Imipramine is the one more p[rescribed and researched in USA. They’re brothers. (Aren’t we all 
)))) blah -Mike
Philip – Hide quoted text — Show quoted text – Can someone please tell me about this drug Anafranil as I am taking this and xanax at the moment, and Anafranil caused me to panic yesterday big time.
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Regarding an earlier post, so, what I am being told is that there is little chance of me suddenly stopping breathing, even though it feels that way at times…trust me, I need reassurance on this one. Also, I was told when I was a kid "don’t put so much food in your mouth or you will choke" and it never actually occurred, but I wonder if the number of times i have been told I eat slow and that I will choke to death have caught up to me? I also was told a story about a guy getting rice stuck in his windpipe and dying, so since high school, I have problems eating it. And now, I spit a lot for fear of choking on my own saliva…silly isn’t it? What I want to know is: what are the actual chances of this happening???? By the way, if Kava Kava is the shit I am thinking of, well, I was in Fiji a while back and had some of that. It is a liquid that is reminiscent of thick Guiness and is drank from a bowl. It numbs the throat and is some sort of aphrodesiac…nasty. Definitely not a cure to anxiety sufferers…
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david sheen schreef: Can someone please tell me about this drug Anafranil as I am taking this and xanax at the moment, and Anafranil caused me to panic yesterday big time.
Anafranil (clomipramine) is an older and well-researched antidepressant of the tricyclic variety. In combination with a benzo it gave me more than eight years of functioning *normally*. How long have you been taking Anafranil? Like all AD’s (be they TCA’s, SSRI’s or MAOI’s or whatever) Anafranil will worsen your symptoms in the initital stage because your body needs to adjust to it. If you’re still at an early stage you might want to give it a chance, which means that you have to take it at least op to 6-8 weeks to be able to evaluate it’s effect. It is best to start at a very low dose (25 mg) and then raise it (50 mg by the end of the first week, then 75 mg and 100 mg after two weeks). Xanax PRN should take care of most breakthrough attacks. Therapeutic dosage for Anafranil is very personal. I did well at 75 mg but it’s common to take much more, up to 300 mg even. Hope this helps some and please keep us posted. Philip Peters
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ANafranil is an old tricyclic. I _think_ it works on serotonin, epinephrine, and dopamine. It didn’t do me any good except on the higher dose (150mg/day) it caused me to do thinks like fall asleep and off the toilet, wake up on the bedroom floor, etc. At 50mg/day I got more and more depressed (dont’ blame the Anafranil, but it didn’t help). It is primarily indicated for OCD but is also used for panic and depression. -Mike – Hide quoted text — Show quoted text – Can someone please tell me about this drug Anafranil as I am taking this and xanax at the moment, and Anafranil caused me to panic yesterday big time.
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Can someone please tell me about this drug Anafranil as I am taking this and xanax at the moment, and Anafranil caused me to panic yesterday big time.
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I’ve been on Anafranil for 7 months now and it’s really working, though it DO has some sideeffects (at least on me…)
Hi ! What is your anafranil daily dose ? thanks.
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Hi again! Right now my daily dose is upped to 150mg cuz my body breaks down these meds very fast… D’man
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I have been on Prozac which is very similar and it really helps. It could take a few months to do much of anything though.
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Hi! I’ve been on Anafranil for 7 months now and it’s really working, though it DO has some sideeffects (at least on me…) I got an increased appetite, leading to 20kg weight gain. Also, during the first weeks I lost all feelings of lust, couldn’t have sex at all and a constantly dry mouth. These later two sideeffects vanished after a couple of weeks. The Anafranil is a general anti-depressant with a energy-booster and with some people it has the opposite effect, i.e it can cause panic attacks, this is not common though and I have not noticed it… So, if you get the right dozage and stay aware of what you eat (when and how much…) you’ll be fine with Anafranil… If you wanna write to me, like if there is anything else you need to know, drop a post to D’man in this group with your mail address and I’ll mail you… Love D’man
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I was recently prescribed anafranil by my family doctor, and I would be interested in hearing from anyone else out there who has tried this medication. This is my first time using medication to control my anxiety, and any feedback would be helpful. Thanks, C.N.
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